2nd year Immuniology 2nd year immunology for universityof strathclyde

2nd year Immuniology 2nd year immunology for universityof strathclyde

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What are the 3 key functions of antibodies? Neutralisation, Opsonisation, Complement
what is the functional activity of IgA Neutralisation, Opsonisation and activation of compliment system
what is the functional activity of IgM Neutralisation, Opsonisation and activation of compliment system
what is the functional activity of IgG Dependant on subclass but can include Neutralisation, Opsonisation and activation of compliment system, sensitisation of mast cells and NK cell functions
what is the functional activity of IgE sensitisation of mast cells
Describe IgG most abundant antibody in the blood, has 4 subtypes, major Ig produced during secondary response
Describe IgA found in blood serum & Mucosal secretions. First line of defence against microorganisms at mucosal surfaces
Describe IgM Produced by and presented on B-Cell surface, found in blood as pentamer, produced during primary response
Describe IgD found in low concentrations, acts as antigen receptor on B-Cell surface
Describe IgE plays a role in acute inflammation, protection against parasites and in allergic reactions
summarise neutralisation antibody binds to toxins/viruses preventing them from binding to cells and causing pathology
summarise opsonisation antibody binds to bacteria allowing phagocytosis to occur by macrophages and neutrophils
summarise compliment a series of proteins that bind to pathogens creating holes in its cell surface
what are the different compliment pathways Lectin, Alternative and classical
Describe the lectin pathway initiated by mannan binding protein (mannan binding ligand, MBL) carbohydrate structures present on microorganisms bind to mannan binding protein, it continues after the formation of C3 as the classical pathway
Describe the Alternative pathway Binds directly to pathogen, begins at compliment 3 (C3) but finishes in the same way as the classical pathway
Describe the classical pathway Activated by IgM/IgG Compliment protein binds to Fc region of antibody, via series of enzymatic reactions it's broken down to form the membrane attack complex, this causes cell lysis in gram negative bacteria and human cells. inflammation occurs
apart from compliment what other soluble mediators are used in immunity Lysozymes, defensisns and cathelicidins
Where are T-Cells selected Thymus
where do T-Cells circulate Lymph nodes
what 2 protein chains paired together on T-Cell receptors Alpha + Beta OR Gamma and Delta
when activated T cells differentiate into 2 types of cells, what are these? CD4+ ‘helper’ T cellCD8+ ‘killer’ T cell
Epitopes from pathogens are presented to T-Cells bound to 1 or both of these complexes MHC1MHC2
MHC Class 1 binds to CD8+ ‘killer’ T cell
MHC class 2 binds to CD4+ ‘helper’ T cell
what are the 2 main CD4+ helper cells T helper 1 (Th1) and T helper 2 (Th2)
What is the role of Th1 Secretion of interferon gamma INFg and macrophage activation
What is the role of Th2 stimulates antibody production and secretion of IL-4 (B-cell activation)
what is extravasation Recruitment of neutrophils to site of infection
What are the stages of phagocytosis RecognitionPseudopod formation.IngestionPhagosomePhagosome /Lysosome formation Digestion

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